Generally, all signs point to the fact that Ketamine might relieve chronic depression and suicidal thoughts. When its effects kick in, it softens the ground enough for other forms of treatment to work more effectively.
What role can Ketamine play in treating depression?
The primary sign would be the drastic reduction of life-threatening thoughts and actions that stem from patients with depression when exposed to Ketamine. That is how you know that the Ketamine is working and the patient responds to treatment. Ketamine can potentially be effective in the treatment of anxiety along with depression from another perspective.
Antidepressants, while seeming to be a good fit for combatting chronic depression, tend to do more harm than good to the patient. Hence, the last few years have seen more patients abandon synthetic antidepressants instead of micro-dosing magic mushrooms or LSD. To date, the reports backing this fact up are nothing but hearsay from those using it. Pollan’s book held a number of these reports, and it remains to see whether these claims will have water under clinical conditions.
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It is understandable why people would shy away from pharmacies, given that they do not precisely permanently cure conditions. Some pharmaceuticals harm you. So, why not go for psychedelics that would do a much better job than antidepressants while still giving pleasure to them?
Nowadays, it is easy for a patient with a mild case of depression that is not as deep as psychosis to explore multiple treatment options with drugs. Such a patient can have an intravenous injection into the body by an anesthesiologist. Private psychiatrists can also administer the medication via shots in the arm. There’s also the option of ordering an oral tablet from a store taking advantage of the remnants of the pandemic era.
Reducing depression symptoms and suicidal thoughts
The British Journal of Psychiatry Open revealed precise results that proved that Ketamine was a viable option for treating bipolar depression. It significantly diminished the symptoms within 1-4 hours of use. The subsequent effects persisted for nothing less than two weeks. Patients who took single or multiple dosages of Ketamine had the least suicidal thoughts, set in four hours after treatment. The effects persisted within three days to a week, according to reports.
Understanding how Ketamine works
The effect of Ketamine on the body system is pretty much like an antidepressant. Its mechanism is nothing like we have ever seen before. As a result, it gave rise to beliefs that depression can be managed in situations where other treatments have failed.
According to researchers, Ketamine could be targeting the NMDA receptors in the nervous system. It binds the receptors and unleashes glutamate synthesis in the spaces between neurons. The glutamate works by activating another type of receptor, the AMPA receptor. The deactivation of NMDA receptors and AMPA activation sets off the release of some molecules that improve the interaction between neurons along new pathways. The scientific term for this is “synaptogenesis,” easily translated as the creation of new synapses.
The effects that often result from this action include changes to thought patterns, mood, and cognition. There are other ways ketamine therapy can reduce depression, such as lowering response to stimuli from inflammation. It indirectly reduces mood disorders and enhances neural communication. These are a few of the suggestive ways Ketamine could likely function in the brain. Other methods could arise with time as the research proceeds further.
Effects of Ketamine
There is no psychoactive substance or drug that doesn’t have its peculiar side effects. These inherent risks underlay the benefits of using such a compound. The benefits of Ketamine, much like other psychedelics, maybe much more than its risks. The common dangers of Ketamine are:
- increased blood pressure
- Cause distortion of reality
- Influence perception
A user may feel like they have an out-of-body experience. The change in perception could be the first thing that gets influenced due to the hysteria it can initiate. But it doesn’t last long as it dissipates almost as quickly as it starts.
When you use an Esketamine nasal spray, the same effects may persist, but it would differ in intensity and the time when the effects seep in. What other factors could influence the results of Ketamine? If consumed frequently, there could be additional side effects that are yet to be discovered. The research into Ketamine is still pretty much a grey area.
Other essential information about Ketamine that you should be wary of are as follows:
- It would help if you had a lower dose of Ketamine for depression than that required for anesthesia
- It has addictive properties similar to opioids. Patients with a history of drug or alcohol abuse need to seek medical opinion about whether Ketamine could be a good option due to its addictive traits. It could add fuel to the fire.
- When administered intravenously, Ketamine kicks in after one or more infusions. But when no reactions are observed in the first, second, and third infusions. They are less likely to work. In this case, consider using other methods of treatment.
Notably, patients get relieved after no more than three ketamine treatments. With different administrations, the positive effects may last longer. The subsequent application will prolong its effects. Many studies recommend that the first round of medicines should not exceed eight. After this, the treatments should either be reduced or stopped entirely. Another option that can be considered is increasing the periods between each treatment.
Can Everyone use Ketamine?
Severe caution must be applied when it comes to the use of Ketamine. Why? Its benefits are glaring, but its adverse effects are yet unknown. As it is with most psychedelic plants, the long-term consequences are hazy. Bryan Bruno, a psychiatrist in New York city’s Lenox Hill Hospital, stated that the benefits do not last long as he projected that they linger for not longer than 7 to 10 days after use. It is considered a drawback because it rules out Ketamine as a cure.
He further stated that some studies indicate that it could negatively affect brain cells and lead to psychotic effects and damage to the bladder. But these may only occur at higher doses. The psychotic results may appear as symptoms at any dose. The onus is to discover what would be the optimum dose and the effects in the long term. According to Dr. Bruno, Depressive patients can count on ketamine therapy if their treatment with FDA-approved solutions fails. For this small group of people, it is essential for the studies into its safety to be hastened.
The user may feel dissociated from reality mildly or much more transient. It is accompanied by high blood pressure and increased heart rate. It would generally cause discontinuation of treatment in other cases, but it is not a consistent turn of events in ketamine treatments.
The feeling of disconnection may start right from the instance of infusion. The patient may feel a little floaty for about 45 minutes. The process may be accompanied by nausea. Ketamine soothes in a way that functions in a way that is similar to the effects of SSRIs. Users report having clear thoughts and a light burden of depression. They also say renewed energy for activities. A user, Nicole Bayman, reported no lasting side effects. She stated the infusion itself felt like a high, although more intense.
Another user named Molly Shea reported that she felt like she got induced into a deep sleep during the administration of Ketamine. Now, she gets the infusion in a 3-week interval. No treatment session exceeds 90 minutes. She reports feeling drowsy, but it was not that deep. She could hear people talking and was conscious of where she was. Molly had to close her eyes because she felt a rush of colors and ideas flowing into her mind. It felt as if another pathway of thought was opened in her mind. Dr. Levine stated that it lacks the potential to initiate addiction despite all these effects. Why? Because it was administered to patients under clinical conditions and they do not have access to it at home. However, the danger lies when used with other drugs such as Xanax or any other Benzodiazepines. They tend to take the edge off the antidepressant effect of Ketamine. And that is bad news on any day!
With all that we have learned about Ketamine use and its potential for therapy, it is not one we can recommend on self-prescription. As numerous as its benefits are, adequate care must be taken not to err on the side of caution. Taking Ketamine at high doses is a bad idea and using it along with other drugs or antidepressants is an equally terrible idea. You can seek expert opinion before you can attempt to buy Ketamine. For a personal consultation and a certified avenue to buy Ketamine.